In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.
نویسندگان
چکیده
In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 38 12 شماره
صفحات -
تاریخ انتشار 1994